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KMID : 0380020080230010077
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 1 p.77 ~ p.82
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Antioxidant Effects and Melanin Inhibitory Effect of Natural Pimpinella komarovii Extracts in Jeju Island
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Kang Min-Chul
Lee Ju-Yeop
Lee Jung-A
Han Jong-Heon
Kim Bong-Seok
Kim Gi-Ok
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Abstract
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We investigated several biological activities using the ethanol extract and its fractions from Pimpinella komarovii leaves to evaluate the usefulness of its extract as a functional biomaterial. The ethanol extract showed antioxidant activities, such as DPPH scavenging activity . superoxide scavenging activity , and xanthine oxidase inhibitory activity . Its EtOAc fraction showed the strongest antioxidant activities among several fractions. The inhibitory effect of ethanol extract on tyrosinase activity was higher than water fraction. When of EtOAc fraction was applied, the inhibition ratio of tyrosinase activity was much higher (42%) than that of melasolv. The EtOAc fraction also showed higher inhibitory effect on melanogenesis in Melan-a cells. The n-hexane and EtOAc fractions dose-dependently inhibited the NO production in a RAW 264.7 cells. These results suggest that extract of Pimpinella komarovii could be used as functional biomaterial in developing a skin whitening agent having the antioxidant activity.
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KEYWORD
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Pimpinella komarovii, antioxidant activity, tyrosinase activity, melanogenesis
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